About mfsig.com
One signed file. Every σ-profile. Forever auditable. We bring COSMO-RS into the open, replayable era — and extend it from single molecules to whole formulations.
Make σ-profile a contract, not a screenshot.
For thirty years, COSMO-RS results have been delivered as PDF reports, vendor-locked binaries, or hand-curated CSVs. Nobody could verify them, replay them, or compose them across labs. We built.mfsig so that every σ-profile is a tamper-evident JSON file — physics inside, SHA-256 outside, open spec, no licence required to read it.
Honest before fast
Every benchmark we publish is reproducible from the artefacts we ship. We list our SOTA rank as #6 of 12 on FreeSolv, not #1, because that's where the bias-corrected LOO MAE lands. We don't market 'fast pipeline' — we market 'verifiable σ-profile'.
Open spec, paid quality
The .mfsig schema, conversion CLI, and σ-profile reader are open-source. Compute at Pro / Platinum / Reference grade is paid — that's what funds the cohort calibration, audit-pack QA, and reproducibility infrastructure. The format never gets paywalled.
From σ¹ to σⁿ
Single molecules today, formulations tomorrow. The strategic arc on the roadmap takes σ-profile from one cavity to multi-component pharmaceutical formulations — the same audit umbrella the whole way up.
What we stand on
database.txt SHA 2d13f095713bc39b.